› 3rny

X-ray diffraction
2.7Å resolution

Crystal structure of human RSK1 C-terminal kinase domain

Released:
DOI: 10.2210/pdb3rny/pdb
PDB entry 3rny coloured by chain, front view.
PDB entry 3rny coloured by chain, side view.
PDB entry 3rny coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the autoinhibition of the C-terminal kinase domain of human RSK1.
Li D, Fu TM, Nan J, Liu C, Li LF, Su XD
Acta Crystallogr D Biol Crystallogr 68 680-5 (2012)
PMID: 22683790

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172282 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 38.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15418 (Residues: 410-735; Coverage: 44%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BSRF BEAMLINE 3W1A
Spacegroup: P21
Unit cell:
a: 39.86Å b: 143.47Å c: 59.92Å
α: 90° β: 95.77° γ: 90°
R-values:
R R work R free
0.191 0.188 0.238
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.
Utepbergenov et al. (2013)
6 other articles

3 mentions without citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
2 more