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Crystal structure of CD4 mutant bound to HLA-DR1

X-ray diffraction
2.4Å resolution
PDB entry 3s4s coloured by chain, front view.
PDB entry 3s4s coloured by chain, side view.
PDB entry 3s4s coloured by chain, top view.
Source organisms:
Assembly composition:
hetero tetramer (preferred)
Entry contents: 4 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 25823.25 Å2
Buried surface area: 8764.02 Å2
Dissociation area: 590.01 Å2
Dissociation energy (ΔGdiss): -3.36 kcal/mol
Dissociation entropy (TΔSdiss): 12.82 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134522
Assembly 2
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Multimeric state: hetero tetramer
Accessible surface area: 25605.77 Å2
Buried surface area: 9356.08 Å2
Dissociation area: 605.01 Å2
Dissociation energy (ΔGdiss): -2.41 kcal/mol
Dissociation entropy (TΔSdiss): 12.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134522

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chains: A, D
Length: 182 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3s4s, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3s4s, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3s4s, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chains: B, E
Length: 193 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01911 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3s4s, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3s4s, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3s4s, assembly 1, top view.
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Hemagglutinin HA1 chain
Chains: C, F
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus (A/Swine/Netherlands/L2/93(H3N2))
Expression system: Not provided
UniProt:
  • Canonical: P03437 (Residues: 322-334; Coverage: 2%)
Gene name: HA
Hemagglutinin HA1 chain in PDB entry 3s4s, assembly 1, front view.
Hemagglutinin HA1 chain in PDB entry 3s4s, assembly 1, side view.
Hemagglutinin HA1 chain in PDB entry 3s4s, assembly 1, top view.
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T-cell surface glycoprotein CD4
Chains: G, H
Length: 191 amino acids
Theoretical weight: 21.26 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01730 (Residues: 26-203; Coverage: 41%)
Gene name: CD4
Pfam:
InterPro:
CATH: Immunoglobulins
T-cell surface glycoprotein CD4 in PDB entry 3s4s, assembly 1, front view.
T-cell surface glycoprotein CD4 in PDB entry 3s4s, assembly 1, side view.
T-cell surface glycoprotein CD4 in PDB entry 3s4s, assembly 1, top view.
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