› 3s94

X-ray diffraction
2.8Å resolution

Crystal structure of LRP6-E1E2

Released:
DOI: 10.2210/pdb3s94/pdb
PDB entry 3s94 coloured by chain, front view.
PDB entry 3s94 coloured by chain, side view.
PDB entry 3s94 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Cheng Z, Biechele T, Wei Z, Morrone S, Moon RT, Wang L, Xu W
Nat Struct Mol Biol 18 1204-10 (2011)
PMID: 21984209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 619 amino acids
Theoretical weight: 70.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75581 (Residues: 20-630; Coverage: 38%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 70.54Å b: 144.51Å c: 70.76Å
α: 90° β: 96° γ: 90°
R-values:
R R work R free
0.24 0.237 0.296
Expression system: Spodoptera frugiperda

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Citations

31 review citations

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17 mentions without citation

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