› 3sbw

X-ray diffraction
2.28Å resolution

Crystal structure of the complex between the extracellular domains of mouse PD-1 mutant and human PD-L1

Released:
DOI: 10.2210/pdb3sbw/pdb
PDB entry 3sbw coloured by chain, front view.
PDB entry 3sbw coloured by chain, side view.
PDB entry 3sbw coloured by chain, top view.
Source organisms:
Entry authors: Lazar-Molnar E, Ramagopal UA, Cao E, Nathenson SG, Almo SC

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-169696 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Programmed cell death protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 13.22 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02242 (Residues: 34-150; Coverage: 44%)
Gene names: Pd1, Pdcd1
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Programmed cell death 1 ligand 1 Chain: C
Molecule details ›
Chain: C
Length: 222 amino acids
Theoretical weight: 25.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZQ7 (Residues: 19-239; Coverage: 81%)
Gene names: B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 56.778Å b: 62.843Å c: 160.863Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.27
Expression system: Escherichia coli BL21(DE3)

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