› 3smt

X-ray diffraction
2.04Å resolution

Crystal structure of human SET domain-containing protein3

Released:
DOI: 10.2210/pdb3smt/pdb
PDB entry 3smt coloured by chain, front view.
PDB entry 3smt coloured by chain, side view.
PDB entry 3smt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Zeng H, Walker JR, Loppnau P, Bountra C, Weigelt J, Arrowsmith CH, Edwards AM, Min J, Wu H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N(tau)-methyl-L-histidine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-183170 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin-histidine N-methyltransferase Chain: A
Molecule details ›
Chain: A
Length: 497 amino acids
Theoretical weight: 57.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86TU7 (Residues: 2-498; Coverage: 84%)
Gene names: C14orf154, SETD3
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand SAM 1 x SAM
4 bound ligands:
Ligand ARS 2 x ARS
Ligand PG4 1 x PG4
Ligand ACT 2 x ACT
Ligand UNX 11 x UNX
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P3121
Unit cell:
a: 113.864Å b: 113.864Å c: 83.57Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.259
Expression system: Escherichia coli

Quick links