› 3sop

X-ray diffraction
2.88Å resolution

Crystal Structure Of Human Septin 3 GTPase Domain

Released:
DOI: 10.2210/pdb3sop/pdb
PDB entry 3sop coloured by chain, front view.
PDB entry 3sop coloured by chain, side view.
PDB entry 3sop coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure and properties of septin 3: a possible missing link in septin filament formation.
Macedo JN, Valadares NF, Marques IA, Ferreira FM, Damalio JC, Pereira HM, Garratt RC, Araujo AP
Biochem J 450 95-105 (2013)
PMID: 23163726

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neuronal-specific septin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 31.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UH03 (Residues: 60-329; Coverage: 75%)
Gene names: SEP3, SEPT3, SEPTIN3
Sequence domains: Septin
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 2 x MG
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2221
Unit cell:
a: 52.244Å b: 150.414Å c: 157.997Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.251 0.272
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Septin Mutations in Human Cancers.
Angelis et al. (2016)
3 more

6 mentions without citation

Septin structure and filament assembly.
Valadares et al. (2017)
5 more