› 3syx

X-ray diffraction
2.45Å resolution

Crystal Structure of the WH1 domain from human sprouty-related, EVH1 domain-containing protein. Northeast Structural Genomics Consortium Target HR5538B.

Released:
DOI: 10.2210/pdb3syx/pdb
PDB entry 3syx coloured by chain, front view.
PDB entry 3syx coloured by chain, side view.
PDB entry 3syx coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vorobiev S, Su M, Seetharaman J, Sahdev S, Xiao R, Ciccosanti C, Shastry R, Everett JK, Nair R, Acton TB, Rost B, Montelione GT, Tong L, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182285 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sprouty-related, EVH1 domain-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7Z699 (Residues: 13-131; Coverage: 27%)
Gene name: SPRED1
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

1 bound ligand:
Ligand YT3 1 x YT3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3112
Unit cell:
a: 52.754Å b: 52.754Å c: 121.638Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.228 0.271
Expression system: Escherichia coli BL21(DE3)

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