› 3t5d

X-ray diffraction
3.3Å resolution

Crystal structure of Septin 7 in complex with GDP

Released:
DOI: 10.2210/pdb3t5d/pdb
PDB entry 3t5d coloured by chain, front view.
PDB entry 3t5d coloured by chain, side view.
PDB entry 3t5d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and biochemical properties of Sept7, a unique septin required for filament formation.
Zent E, Vetter I, Wittinghofer A
Biol Chem 392 791-7 (2011)
PMID: 21824007

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Septin-7 Chains: A, C
Molecule details ›
Chains: A, C
Length: 274 amino acids
Theoretical weight: 31.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16181 (Residues: 48-316; Coverage: 62%)
Gene names: CDC10, SEPT7, SEPTIN7
Sequence domains: Septin
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand GDP 2 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 82.363Å b: 82.363Å c: 210.598Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.287 0.285 0.318
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Septins: the fourth component of the cytoskeleton.
Mostowy et al. (2012)
8 more

6 mentions without citation

Septin structure and filament assembly.
Valadares et al. (2017)
5 more