› 3t6a

X-ray diffraction
2.4Å resolution

Structure of the C-terminal domain of BCAR3

Released:
DOI: 10.2210/pdb3t6a/pdb
PDB entry 3t6a coloured by chain, front view.
PDB entry 3t6a coloured by chain, side view.
PDB entry 3t6a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.
Mace PD, Wallez Y, Dobaczewska MK, Lee JJ, Robinson H, Pasquale EB, Riedl SJ
Nat Struct Mol Biol 18 1381-7 (2011)
PMID: 22081014

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131126 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Breast cancer anti-estrogen resistance protein 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 333 amino acids
Theoretical weight: 38.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75815 (Residues: 502-825; Coverage: 39%)
Gene names: BCAR3, NSP2, SH2D3B, UNQ271/PRO308
Sequence domains: RasGEF domain
Structure domains: Ras guanine-nucleotide exchange factors catalytic domain

Ligands and Environments

2 bound ligands:
Ligand POG 2 x POG
Ligand UNX 8 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 50.233Å b: 151.889Å c: 196.503Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.244
Expression system: Escherichia coli

Quick links

Citations

3 review citations

p130Cas: a key signalling node in health and disease.
Barrett et al. (2013)
2 more

3 mentions without citation

Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.
Wallez et al. (2014)
2 more