› 3t7u

X-ray diffraction
2.9Å resolution

A NeW Crystal structure of APC-ARM

Released:
DOI: 10.2210/pdb3t7u/pdb
PDB entry 3t7u coloured by chain, front view.
PDB entry 3t7u coloured by chain, side view.
PDB entry 3t7u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility.
Zhang Z, Lin K, Gao L, Chen L, Shi X, Wu G
Biochem Biophys Res Commun 412 732-6 (2011)
PMID: 21871439

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenomatous polyposis coli protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 378 amino acids
Theoretical weight: 42.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25054 (Residues: 407-775; Coverage: 13%)
Gene names: APC, DP2.5
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand PO4 2 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P31
Unit cell:
a: 72.496Å b: 72.496Å c: 129.981Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.271 0.269 0.313
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Normal Mode Analysis as a Routine Part of a Structural Investigation.
Bauer et al. (2019)
1 more

2 mentions without citation

The structural biology of canonical Wnt signalling.
Agostino et al. (2020)
1 more