› 3t8s

X-ray diffraction
3.77Å resolution

Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor

Released:
DOI: 10.2210/pdb3t8s/pdb
PDB entry 3t8s coloured by chain, front view.
PDB entry 3t8s coloured by chain, side view.
PDB entry 3t8s coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Apo and InsP₃-bound crystal structures of the ligand-binding domain of an InsP₃ receptor.
Lin CC, Baek K, Lu Z
Nat Struct Mol Biol 18 1172-4 (2011)
PMID: 21892169

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 585 amino acids
Theoretical weight: 66.1 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P29994 (Residues: 7-602; Coverage: 21%)
Gene names: Insp3r, Itpr1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand I3P 1 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 159.829Å b: 84.877Å c: 95.09Å
α: 90° β: 116.92° γ: 90°
R-values:
R R work R free
0.278 0.277 0.292
Expression system: Escherichia coli

Quick links

Citations

17 review citations

Ryanodine receptors: structure and function.
Van Petegem F. (2012)
16 more

7 mentions without citation

Toward a high-resolution structure of IP₃R channel.
Serysheva II. (2014)
6 more