› 3tt9

X-ray diffraction
1.55Å resolution

Crystal structure of the stable degradation fragment of human plakophilin 2 isoform a (PKP2a) C752R variant

Released:
DOI: 10.2210/pdb3tt9/pdb
PDB entry 3tt9 coloured by chain, front view.
PDB entry 3tt9 coloured by chain, side view.
PDB entry 3tt9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations.
Kirchner F, Schuetz A, Boldt LH, Martens K, Dittmar G, Haverkamp W, Thierfelder L, Heinemann U, Gerull B
Circ Cardiovasc Genet 5 400-11 (2012)
PMID: 22781308

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189290 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plakophilin-2 Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 26.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99959 (Residues: 346-620; Coverage: 26%)
Gene name: PKP2
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 46.35Å b: 63.038Å c: 74.953Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.158 0.192
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Molecular mechanisms of arrhythmogenic cardiomyopathy.
Austin et al. (2019)
15 more

6 mentions without citation

Mechanistic basis of desmosome-targeted diseases.
Al-Jassar et al. (2013)
5 more