› 3u4x

X-ray diffraction
2.16Å resolution

Crystal structure of a lectin from Camptosema pedicellatum seeds in complex with 5-bromo-4-chloro-3-indolyl-alpha-D-mannose

Released:
DOI: 10.2210/pdb3u4x/pdb
PDB entry 3u4x coloured by chain, front view.
PDB entry 3u4x coloured by chain, side view.
PDB entry 3u4x coloured by chain, top view.
Source organism: Bionia pedicellata
Primary publication:
Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite.
Souza Teixeira C, da Silva HC, de Moura TR, Pereira-Júnior FN, do Nascimento KS, Nagano CS, Sampaio AH, Delatorre P, Rocha BA, Cavada BS
J Biochem 152 87-98 (2012)
PMID: 22554687

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125393 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lectin CPL Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 25.32 KDa
Source organism: Bionia pedicellata
UniProt:
  • Canonical: J9PBR3 (Residues: 1-236; Coverage: 100%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand MN 1 x MN
Ligand XMM 1 x XMM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE D03B-MX1
Spacegroup: I222
Unit cell:
a: 65.94Å b: 66.78Å c: 107.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.237

Quick links

Citations

2 review citations

Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives.
Barre et al. (2021)
1 more

1 mention without citation

ConA-Like Lectins: High Similarity Proteins as Models to Study Structure/Biological Activities Relationships.
Cavada et al. (2018)