› 3u9j

X-ray diffraction
1.6Å resolution

Crystal structure of oxidized human FBXL5 hemerythrin like domain

Released:
DOI: 10.2210/pdb3u9j/pdb
PDB entry 3u9j coloured by chain, front view.
PDB entry 3u9j coloured by chain, side view.
PDB entry 3u9j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis of iron sensing by the human F-box protein FBXL5.
Shu C, Sung MW, Stewart MD, Igumenova TI, Tan X, Li P
Chembiochem 13 788-91 (2012)
PMID: 22492618

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193840 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box/LRR-repeat protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 19.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKA1 (Residues: 1-160; Coverage: 23%)
Gene names: FBL4, FBL5, FBXL5, FLR1
Sequence domains: Hemerythrin HHE cation binding domain
Structure domains: nmb1532 protein domain like

Ligands and Environments

1 bound ligand:
Ligand FE 4 x FE
1 modified residue:
Ligand MSE 14 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21212
Unit cell:
a: 55.082Å b: 77.343Å c: 78.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.217
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Mechanisms and function of substrate recruitment by F-box proteins.
Skaar et al. (2013)
2 more

3 mentions without citation

The structural basis of iron sensing by the human F-box protein FBXL5.
Shu et al. (2012)
2 more