› 3ub4

X-ray diffraction
3.1Å resolution

S180L variant of TIR domain of Mal/TIRAP

Released:
DOI: 10.2210/pdb3ub4/pdb
PDB entry 3ub4 coloured by chain, front view.
PDB entry 3ub4 coloured by chain, side view.
PDB entry 3ub4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into TIR domain specificity of the bridging adaptor Mal in TLR4 signaling.
Lin Z, Lu J, Zhou W, Shen Y
PLoS One 7 e34202 (2012)
PMID: 22485159

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157720 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P58753 (Residues: 78-221; Coverage: 65%)
Gene names: MAL, TIRAP
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

1 bound ligand:
Ligand DTV 1 x DTV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P43212
Unit cell:
a: 87.172Å b: 87.172Å c: 80.98Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.226 0.254
Expression system: Escherichia coli

Quick links

Citations

10 review citations

TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis.
Kuzmich et al. (2017)
9 more

2 mentions without citation

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway.
Guven-Maiorov et al. (2015)
1 more