› 3uf5

X-ray diffraction
2.8Å resolution

Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine

Released:
DOI: 10.2210/pdb3uf5/pdb
PDB entry 3uf5 coloured by chain, front view.
PDB entry 3uf5 coloured by chain, side view.
PDB entry 3uf5 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1.
Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN
Nat Struct Mol Biol 19 938-47 (2012)
PMID: 22902366

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 43 kDa subunit Chains: A, B
Molecule details ›
Chains: A, B
Length: 153 amino acids
Theoretical weight: 17.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P07141 (Residues: 33-181; Coverage: 29%)
Gene names: Csf1, Csfm
Sequence domains: Macrophage colony stimulating factor-1 (CSF-1)
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 36.32Å b: 68.69Å c: 144.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.21 0.258
Expression system: Escherichia coli

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Citations

13 review citations

CSF-1 receptor signaling in myeloid cells.
Stanley et al. (2014)
12 more