› 3up1

X-ray diffraction
2.15Å resolution

Crystal structure of the unliganded human interleukin-7 receptor extracellular domain

Released:
DOI: 10.2210/pdb3up1/pdb
PDB entry 3up1 coloured by chain, front view.
PDB entry 3up1 coloured by chain, side view.
PDB entry 3up1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural reorganization of the interleukin-7 signaling complex.
McElroy CA, Holland PJ, Zhao P, Lim JM, Wells L, Eisenstein E, Walsh ST
Proc Natl Acad Sci U S A 109 2503-8 (2012)
PMID: 22308406

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Interleukin-7 receptor subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 25.69 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: P16871 (Residues: 21-239; Coverage: 50%)
Gene name: IL7R
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand FUC 2 x FUC
Ligand SO4 5 x SO4
Ligand GOL 4 x GOL
Ligand NGA 1 x NGA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: I222
Unit cell:
a: 81.424Å b: 101.259Å c: 151.994Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.257
Expression system: Drosophila

Quick links

Citations

11 review citations

IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia.
Ribeiro et al. (2013)
10 more

11 mentions without citation

Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway.
Walsh ST. (2012)
10 more