› 3ut3

X-ray diffraction
2.42Å resolution

A novel PAI-I inhibitor and its structural mechanism

Released:
DOI: 10.2210/pdb3ut3/pdb
PDB entry 3ut3 coloured by chain, front view.
PDB entry 3ut3 coloured by chain, side view.
PDB entry 3ut3 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lin ZH, Hong ZB, Shi XL, Hu LH, Andreasen PA, Huang MD

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138523 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 375 amino acids
Theoretical weight: 42.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05121 (Residues: 28-402; Coverage: 99%)
Gene names: PAI1, PLANH1, SERPINE1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand EMJ 1 x EMJ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 65.252Å b: 74.953Å c: 103.775Å
α: 90.89° β: 93.33° γ: 115.72°
R-values:
R R work R free
0.205 0.202 0.245
Expression system: Escherichia coli

Quick links