› 3uun

X-ray diffraction
2.3Å resolution

Crystal Structure of N-terminal first spectrin repeat of dystrophin

Released:
DOI: 10.2210/pdb3uun/pdb
PDB entry 3uun coloured by chain, front view.
PDB entry 3uun coloured by chain, side view.
PDB entry 3uun coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries.
Muthu M, Richardson KA, Sutherland-Smith AJ
PLoS One 7 e40066 (2012)
PMID: 22911693

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dystrophin Chains: A, B
Molecule details ›
Chains: A, B
Length: 119 amino acids
Theoretical weight: 13.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11532 (Residues: 338-456; Coverage: 3%)
Gene name: DMD
Sequence domains: Spectrin repeat
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P3221
Unit cell:
a: 76.04Å b: 76.04Å c: 66.49Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.19 0.26
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pathoproteomic profiling of the skeletal muscle matrisome in dystrophinopathy associated myofibrosis.
Holland et al. (2016)
1 more

5 mentions without citation

The crystal structures of dystrophin and utrophin spectrin repeats: implications for domain boundaries.
Muthu et al. (2012)
4 more