› 3ux1

X-ray diffraction
2.8Å resolution

Structural Characterization of Adeno-Associated Virus Serotype 9

Released:
DOI: 10.2210/pdb3ux1/pdb
PDB entry 3ux1 coloured by chain, front view.
PDB entry 3ux1 coloured by chain, side view.
PDB entry 3ux1 coloured by chain, top view.
Source organism: Adeno-associated virus 9
Primary publication:
Structural insight into the unique properties of adeno-associated virus serotype 9.
DiMattia MA, Nam HJ, Van Vliet K, Mitchell M, Bennett A, Gurda BL, McKenna R, Olson NH, Sinkovits RS, Potter M, Byrne BJ, Aslanidi G, Zolotukhin S, Muzyczka N, Baker TS, Agbandje-McKenna M
J Virol 86 6947-58 (2012)
PMID: 22496238

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 58.47 KDa
Source organism: Adeno-associated virus 9
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q6JC40 (Residues: 219-736; Coverage: 70%)
Gene name: cap
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P32
Unit cell:
a: 250.68Å b: 250.68Å c: 632.92Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.284 0.283 0.282
Expression system: Spodoptera frugiperda

Quick links

Citations

28 review citations

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy.
Naso et al. (2017)
27 more

38 mentions without citation

Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry.
Large et al. (2021)
37 more