3ux9

X-ray diffraction
2.8Å resolution

Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-208436 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interferon alpha-1/13 Chains: A, C
Molecule details ›
Chains: A, C
Length: 169 amino acids
Theoretical weight: 19.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01562 (Residues: 24-189; Coverage: 100%)
Gene names: IFNA1, IFNA13
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;
ScFv antibody Chains: B, D
Molecule details ›
Chains: B, D
Length: 256 amino acids
Theoretical weight: 27.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 236.225Å b: 91.945Å c: 43.633Å
α: 90° β: 99.75° γ: 90°
R-values:
R R work R free
0.186 0.183 0.243
Expression system: Escherichia coli