Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA polymerase family X
- DNA polymerase family X, beta-like
- Nucleotidyltransferase superfamily
- Helix-hairpin-helix DNA-binding motif, class 1
- DNA-directed DNA polymerase X
- DNA polymerase lambda lyase domain superfamily
- DNA polymerase, thumb domain superfamily
- DNA polymerase beta, thumb domain
4 more domains
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
DNA polymerase beta (preferred)
PDBe Complex ID:
PDB-CPX-139217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA polymerase beta
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 38.39 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 335 amino acids
Theoretical weight: 38.39 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
- Canonical:
P06766 (Residues: 1-335; Coverage: 100%)
Sequence domains:
- Helix-hairpin-helix domain
- Fingers domain of DNA polymerase lambda
- DNA polymerase beta palm
- DNA polymerase beta thumb
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU
Spacegroup:
P21
Expression system: Escherichia coli
