› 3v6a

X-ray diffraction
2.6Å resolution

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

Released:
DOI: 10.2210/pdb3v6a/pdb
PDB entry 3v6a coloured by chain, front view.
PDB entry 3v6a coloured by chain, side view.
PDB entry 3v6a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.
Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI
J Biol Chem 287 10727-37 (2012)
PMID: 22334682

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189872 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis inhibitor 5 Chain: A
Molecule details ›
Chain: A
Length: 474 amino acids
Theoretical weight: 53.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BZZ5 (Residues: 1-454; Coverage: 87%)
Gene names: API5, MIG8
Sequence domains: Apoptosis inhibitory protein 5 (API5)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P212121
Unit cell:
a: 46.376Å b: 88.615Å c: 136.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.213 0.25
Expression system: Escherichia coli

Quick links

Citations

16 citation in other articles

Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.
Mayank et al. (2015)
15 more

1 mention without citation

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.
Han et al. (2012)