› 3v6o

X-ray diffraction
1.95Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-211271 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Leptin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 206 amino acids
Theoretical weight: 23.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48357 (Residues: 428-633; Coverage: 18%)
Gene names: DB, LEPR, OBR
Sequence domains: Obesity receptor immunoglobulin like domain
Structure domains: Immunoglobulins
Monoclonal antibody 9F8 fab fragment Heavy chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 221 amino acids
Theoretical weight: 23.59 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Monoclonal antibody 9F8 fab fragment Light chain Chains: E, F
Molecule details ›
Chains: E, F
Length: 215 amino acids
Theoretical weight: 23.87 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

5 bound ligands:
Ligand CYS 2 x CYS
Ligand EDO 31 x EDO
Ligand ACT 6 x ACT
Ligand NA 1 x NA
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 89.814Å b: 118.829Å c: 171.281Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.171 0.214
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Leptin-cytokine crosstalk in breast cancer.
Newman et al. (2014)
9 more

14 mentions without citation

Leptin and leptin receptor: analysis of a structure to function relationship in interaction and evolution from humans to fish.
Prokop et al. (2012)
13 more