› 3wsy

X-ray diffraction
3.11Å resolution

SorLA Vps10p domain in complex with its own propeptide fragment

Released:
DOI: 10.2210/pdb3wsy/pdb
PDB entry 3wsy coloured by chain, front view.
PDB entry 3wsy coloured by chain, side view.
PDB entry 3wsy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for amyloidogenic peptide recognition by sorLA.
Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J
Nat Struct Mol Biol 22 199-206 (2015)
PMID: 25643321

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187716 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sortilin-related receptor Chain: A
Molecule details ›
Chain: A
Length: 678 amino acids
Theoretical weight: 76.57 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q92673 (Residues: 86-753; Coverage: 31%)
Gene names: C11orf32, SORL1
Sequence domains:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1
Sortilin-related receptor Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q92673 (Residues: 42-56; Coverage: 1%)
Gene names: C11orf32, SORL1

Ligands and Environments

1 bound ligand:
Ligand NAG 5 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: I41
Unit cell:
a: 158.186Å b: 158.186Å c: 145.458Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.232
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

12 review citations

Functional Roles of the Interaction of APP and Lipoprotein Receptors.
Pohlkamp et al. (2017)
11 more

5 mentions without citation

Structural insights into SorCS2-Nerve Growth Factor complex formation.
Leloup et al. (2018)
4 more