› 3wsz

X-ray diffraction
3.2Å resolution

SorLA Vps10p domain in complex with Abeta-derived peptide

Released:
DOI: 10.2210/pdb3wsz/pdb
PDB entry 3wsz coloured by chain, front view.
PDB entry 3wsz coloured by chain, side view.
PDB entry 3wsz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for amyloidogenic peptide recognition by sorLA.
Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J
Nat Struct Mol Biol 22 199-206 (2015)
PMID: 25643321

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164231 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Sortilin-related receptor Chain: A
Molecule details ›
Chain: A
Length: 678 amino acids
Theoretical weight: 76.57 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q92673 (Residues: 86-753; Coverage: 31%)
Gene names: C11orf32, SORL1
Sequence domains:
10-mer peptide Chain: C
Molecule details ›
Chain: C
Length: 10 amino acids
Theoretical weight: 729 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P6222
Unit cell:
a: 163.735Å b: 163.735Å c: 121.093Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.274 0.273 0.296
Expression systems:
  • Cricetulus griseus
  • Not provided

Quick links

Citations

11 review citations

Functional Roles of the Interaction of APP and Lipoprotein Receptors.
Pohlkamp et al. (2017)
10 more

2 mentions without citation

Conformational Variability of Amyloid-β and the Morphological Diversity of Its Aggregates.
Yagi-Utsumi et al. (2022)
1 more