› 3x0e

X-ray diffraction
1.84Å resolution

Crystal structure of the ectodomain of human CD81 large extracellular loop (hCD81-LEL)

Released:
DOI: 10.2210/pdb3x0e/pdb
PDB entry 3x0e coloured by chain, front view.
PDB entry 3x0e coloured by chain, side view.
PDB entry 3x0e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An intramolecular bond at cluster of differentiation 81 ectodomain is important for hepatitis C virus entry.
Yang W, Zhang M, Chi X, Liu X, Qin B, Cui S
FASEB J 29 4214-26 (2015)
PMID: 26116703

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157955 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD81 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60033 (Residues: 113-202; Coverage: 38%)
Gene names: CD81, TAPA1, TSPAN28
Sequence domains: Tetraspanin family
Structure domains: Tetraspanin

Ligands and Environments

1 bound ligand:
Ligand MG 5 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 31.124Å b: 77.408Å c: 38.497Å
α: 90° β: 107.94° γ: 90°
R-values:
R R work R free
0.196 0.195 0.225
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F.
Oosterheert et al. (2020)
2 more

2 mentions without citation

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
Zimmerman et al. (2016)
1 more