› 3zh8

X-ray diffraction
2.74Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154422 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C iota type Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 349 amino acids
Theoretical weight: 40.32 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41743 (Residues: 248-596; Coverage: 59%)
Gene names: DXS1179E, PRKCI
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand IOD 12 x IOD
Ligand CL 3 x CL
Ligand C58 3 x C58
Ligand EDO 10 x EDO
1 modified residue:
Ligand TPO 6 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P31
Unit cell:
a: 113.58Å b: 113.58Å c: 82.41Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.21 0.257
Expression system: Spodoptera frugiperda

Quick links

Citations

8 review citations

Targeting Rho GTPase Signaling Networks in Cancer.
Clayton et al. (2020)
7 more

7 mentions without citation

Knowledge-based fragment binding prediction.
Tang et al. (2014)
6 more