› 3zln

X-ray diffraction
2.29Å resolution

Crystal structure of BCL-XL in complex with inhibitor (Compound 3)

Released:
DOI: 10.2210/pdb3zln/pdb
PDB entry 3zln coloured by chain, front view.
PDB entry 3zln coloured by chain, side view.
PDB entry 3zln coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure-guided design of a selective BCL-X(L) inhibitor.
Lessene G, Czabotar PE, Sleebs BE, Zobel K, Lowes KN, Adams JM, Baell JB, Colman PM, Deshayes K, Fairbrother WJ, Flygare JA, Gibbons P, Kersten WJ, Kulasegaram S, Moss RM, Parisot JP, Smith BJ, Street IP, Yang H, Huang DC, Watson KG
Nat Chem Biol 9 390-7 (2013)
PMID: 23603658

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170518 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 20.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 73%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand H0Y 1 x H0Y
Ligand SO4 1 x SO4
Ligand EDO 5 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX
Spacegroup: P41212
Unit cell:
a: 65.911Å b: 65.911Å c: 115.072Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.246
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

78 review citations

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Czabotar et al. (2014)
77 more

9 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
8 more