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Crystal structure of MEK1 in complex with fragment 6

Source organism: Homo sapiens
Biochemical function: ATP binding
Biological process: protein phosphorylation
Cellular component: not assigned

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EC 2.7.12.2: Mitogen-activated protein kinase kinase

Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Systematic name:
ATP:protein phosphotransferase (MAPKKK-activated)
Alternative Name(s):
  • MAP kinase kinase
  • MAP kinase kinase 4
  • MAP kinase kinase 7
  • MAP kinase or ERK kinase
  • MAP2K
  • MAPKK
  • MAPKK1
  • MEK
  • MEK1
  • MEK2
  • MKK
  • MKK2
  • MKK4
  • MKK6
  • MKK7
  • STK27

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00069
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
The deposited structure of PDB entry 3zls contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Dual specificity mitogen-activated protein kinase kinase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008271
Domain description: Serine/threonine-protein kinase, active site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR017441
Domain description: Protein kinase, ATP binding site
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR000719
Domain description: Protein kinase domain
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
IPR011009
Domain description: Protein kinase-like domain superfamily
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1

Structure domains

CATH CATH domains
1.10.510.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Transferase(Phosphotransferase); domain 1
Homology: Transferase(Phosphotransferase) domain 1
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
The deposited structure of PDB entry 3zls contains 1 copy of CATH domain 1.10.510.10 (Transferase(Phosphotransferase); domain 1) in Dual specificity mitogen-activated protein kinase kinase 1. Showing 1 copy in chain A.
3.30.200.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Phosphorylase Kinase; domain 1
Homology: Phosphorylase Kinase; domain 1
Occurring in:
  1. Dual specificity mitogen-activated protein kinase kinase 1
The deposited structure of PDB entry 3zls contains 1 copy of CATH domain 3.30.200.20 (Phosphorylase Kinase; domain 1) in Dual specificity mitogen-activated protein kinase kinase 1. Showing 1 copy in chain A.

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