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Crystal structure of MEK1 in complex with fragment 3

X-ray diffraction
2.12Å resolution
PDB entry 3zlw coloured by chain, front view.
PDB entry 3zlw coloured by chain, side view.
PDB entry 3zlw coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Dual specificity mitogen-activated protein kinase kinase 1
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-169744

Macromolecules

Dual specificity mitogen-activated protein kinase kinase 1
Chain: A
Length: 348 amino acids
Theoretical weight: 38.95 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q02750 (Residues: 37-383; Coverage: 88%)
Gene names: MAP2K1, MEK1, PRKMK1
Pfam: Protein kinase domain
InterPro:
CATH:
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 3zlw, assembly 1, front view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 3zlw, assembly 1, side view.
Dual specificity mitogen-activated protein kinase kinase 1 in PDB entry 3zlw, assembly 1, top view.
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