› 3zon

X-ray diffraction
2.15Å resolution

Human TYK2 pseudokinase domain bound to a kinase inhibitor

Released:
DOI: 10.2210/pdb3zon/pdb
PDB entry 3zon coloured by chain, front view.
PDB entry 3zon coloured by chain, side view.
PDB entry 3zon coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Elkins JM, Wang J, Krojer T, Savitsky P, Chalk R, Daga N, Salah E, Berridge G, Picaud S, von Delft F, Bountra C, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 335 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29597 (Residues: 541-873; Coverage: 28%)
Gene name: TYK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IK1 1 x IK1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P212121
Unit cell:
a: 47.81Å b: 83.72Å c: 91.22Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.268
Expression system: Spodoptera frugiperda

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