› 4a0p

X-ray diffraction
1.9Å resolution

Crystal structure of LRP6P3E3P4E4

Released:
DOI: 10.2210/pdb4a0p/pdb
PDB entry 4a0p coloured by chain, front view.
PDB entry 4a0p coloured by chain, side view.
PDB entry 4a0p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling.
Chen S, Bubeck D, MacDonald BT, Liang WX, Mao JH, Malinauskas T, Llorca O, Aricescu AR, Siebold C, He X, Jones EY
Dev Cell 21 848-61 (2011)
PMID: 22000855

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 628 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75581 (Residues: 629-1244; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 3 x CA
Ligand CL 3 x CL
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: C2
Unit cell:
a: 169.815Å b: 42.699Å c: 119.879Å
α: 90° β: 97.49° γ: 90°
R-values:
R R work R free
0.183 0.181 0.211
Expression system: Homo sapiens

Quick links

Citations

19 review citations

Wnt signaling in development and tissue homeostasis.
Steinhart et al. (2018)
18 more

11 mentions without citation

Wnt signaling in triple-negative breast cancer.
Pohl et al. (2017)
10 more