4a1u

X-ray diffraction
1.54Å resolution

Crystal structure of alpha-beta-foldamer 2c in complex with Bcl-xL

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-128963 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Bcl-2-like protein 11 Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.35 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: O43521 (Residues: 146-163; Coverage: 9%)
Gene names: BCL2L11, BIM
Sequence domains: Bcl-x interacting, BH3 domain

Ligands and Environments

2 bound ligands:
4 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P3121
Unit cell:
a: 54.706Å b: 54.706Å c: 119.168Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.171 0.198
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided