› 4a3n

X-ray diffraction
2.4Å resolution

Crystal Structure of HMG-BOX of Human SOX17

Released:
DOI: 10.2210/pdb4a3n/pdb
PDB entry 4a3n coloured by chain, front view.
PDB entry 4a3n coloured by chain, side view.
PDB entry 4a3n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of human transcription factor Sry-related box 17 binding to DNA.
Gao N, Jiang W, Gao H, Cheng Z, Qian H, Si S, Xie Y
Protein Pept Lett 20 481-8 (2013)
PMID: 23061670

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription factor SOX-17 Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H6I2 (Residues: 68-136; Coverage: 17%)
Gene name: SOX17
Sequence domains: HMG (high mobility group) box
Structure domains: High mobility group box domain

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 94.281Å b: 22.525Å c: 66.668Å
α: 90° β: 129.09° γ: 90°
R-values:
R R work R free
0.202 0.202 0.267
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Molecular basis for the genome engagement by Sox proteins.
Hou et al. (2017)
2 more

2 mentions without citation

Identification of cancer driver genes based on nucleotide context.
Dietlein et al. (2020)
1 more