Function and Biology Details
Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127450 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone deacetylase 3
Molecule details ›
Chains: A, B
Length: 376 amino acids
Theoretical weight: 42.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Length: 376 amino acids
Theoretical weight: 42.92 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
O15379 (Residues: 1-376; Coverage: 88%)
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Nuclear receptor corepressor 2
Molecule details ›
Chains: C, D
Length: 94 amino acids
Theoretical weight: 11.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Myb-like DNA-binding domain
Structure domains: Homeodomain-like
Length: 94 amino acids
Theoretical weight: 11.31 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q9Y618 (Residues: 389-480; Coverage: 4%)
Sequence domains: Myb-like DNA-binding domain
Structure domains: Homeodomain-like
