› 4acc

X-ray diffraction
2.21Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 465 amino acids
Theoretical weight: 52.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P49841 (Residues: 1-420; Coverage: 100%)
Gene name: GSK3B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand DMS 3 x DMS
Ligand 7YG 2 x 7YG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 83.08Å b: 85.81Å c: 177.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.189 0.219
Expression system: Trichoplusia ni

Quick links

Citations

10 review citations

Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging.
Pandey et al. (2016)
9 more

12 mentions without citation

Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis.
Sophia et al. (2016)
11 more