› 4ad7

X-ray diffraction
2.94Å resolution

Crystal structure of full-length N-glycosylated human glypican-1

Released:
DOI: 10.2210/pdb4ad7/pdb
PDB entry 4ad7 coloured by chain, front view.
PDB entry 4ad7 coloured by chain, side view.
PDB entry 4ad7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of N-glycosylated human glypican-1 core protein: structure of two loops evolutionarily conserved in vertebrate glypican-1.
Svensson G, Awad W, Håkansson M, Mani K, Logan DT
J Biol Chem 287 14040-51 (2012)
PMID: 22351761

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152787 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glypican-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 528 amino acids
Theoretical weight: 58.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P35052 (Residues: 24-529; Coverage: 95%)
Gene name: GPC1
Sequence domains: Glypican

Ligands and Environments

1 bound ligand:
Ligand NAG 6 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P21
Unit cell:
a: 47.25Å b: 169.2Å c: 151.71Å
α: 90° β: 94.96° γ: 90°
R-values:
R R work R free
0.221 0.218 0.278
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans.
Iozzo et al. (2015)
9 more

7 mentions without citation

Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators.
Uversky VN. (2014)
6 more