› 4ahm

X-ray diffraction
1.96Å resolution

V113I - Angiogenin mutants and amyotrophic lateral sclerosis - a biochemical and biological analysis

Released:
DOI: 10.2210/pdb4ahm/pdb
PDB entry 4ahm coloured by chain, front view.
PDB entry 4ahm coloured by chain, side view.
PDB entry 4ahm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Thiyagarajan N, Ferguson R, Subramanian V, Acharya KR
Nat Commun 3 1121 (2012)
PMID: 23047679

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand TLA 1 x TLA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 82.269Å b: 118.284Å c: 37.215Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.221
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

A census of human RNA-binding proteins.
Gerstberger et al. (2014)
15 more

1 mention without citation

Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons.
Thiyagarajan et al. (2012)