› 4aiz

X-ray diffraction
1.75Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177736 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, C, D
Molecule details ›
Chains: A, C, D
Length: 108 amino acids
Theoretical weight: 11.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5NV90 (Residues: 1-96; Coverage: 99%)
Gene name: V2-17
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: B
Molecule details ›
Chain: B
Length: 108 amino acids
Theoretical weight: 11.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5NV90 (Residues: 1-96; Coverage: 99%)
Gene name: V2-17
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand CIT 1 x CIT
Ligand 88Q 1 x 88Q
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: C2
Unit cell:
a: 89.402Å b: 40.946Å c: 106.726Å
α: 90° β: 90.15° γ: 90°
R-values:
R R work R free
0.169 0.166 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 citation in other articles

Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Oberti et al. (2017)
6 more

3 mentions without citation

Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD).
Mendoza et al. (2018)
2 more