› 4ap8

X-ray diffraction
2.78Å resolution

Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)

Released:
DOI: 10.2210/pdb4ap8/pdb
PDB entry 4ap8 coloured by chain, front view.
PDB entry 4ap8 coloured by chain, side view.
PDB entry 4ap8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Vollmar M, Kiyani W, Krojer T, Goubin S, Allerston C, Froese DS, von Delft F, Burgess-Brown N, Bountra C, Arrowsmith CH, Edwards A, Yue WW

Function and Biology Details

Reaction catalysed: 
Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132110 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Molybdopterin synthase catalytic subunit Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 135 amino acids
Theoretical weight: 15.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O96007 (Residues: 38-172; Coverage: 72%)
Gene names: MCBPE, MOCO1, MOCS2
Sequence domains: MoaE protein
Structure domains: Molybdopterin biosynthesis MoaE subunit

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P3121
Unit cell:
a: 138.968Å b: 138.968Å c: 159.574Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.172 0.199
Expression system: Escherichia coli BL21(DE3)

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