Function and Biology Details
Reaction catalysed:
Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.
Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Angiotensin-converting enzyme and Bradykinin (preferred)
PDBe Complex ID:
PDB-CPX-133905 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Angiotensin-converting enzyme
Molecule details ›
Chain: A
Length: 598 amino acids
Theoretical weight: 69.15 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella phaffii GS115
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 598 amino acids
Theoretical weight: 69.15 KDa
Source organism: Drosophila melanogaster
Expression system: Komagataella phaffii GS115
UniProt:
- Canonical:
Q10714 (Residues: 17-614; Coverage: 100%)
Sequence domains: Angiotensin-converting enzyme
Bradykinin
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P01042 (Residues: 381-389; Coverage: 1%)
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I03
Spacegroup:
R3
Expression systems:
- Komagataella phaffii GS115
- Not provided
