› 4aze

X-ray diffraction
3.15Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164299 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dual specificity tyrosine-phosphorylation-regulated kinase 1A Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 382 amino acids
Theoretical weight: 44.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13627 (Residues: 128-485; Coverage: 47%)
Gene names: DYRK, DYRK1A, MNB, MNBH
Sequence domains: Protein kinase domain
Structure domains:
DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 1A Chains: E, F, G
Molecule details ›
Chains: E, F, G
Length: 4 amino acids
Theoretical weight: 440 Da
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)

Ligands and Environments

1 bound ligand:
Ligand 3RA 3 x 3RA
2 modified residues:
Ligand SEP 6 x SEP
Ligand PTR 3 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3112
Unit cell:
a: 111.649Å b: 111.649Å c: 301.725Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.218 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

16 review citations

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.
Duchon et al. (2016)
15 more

9 mentions without citation

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview.
Lindberg et al. (2021)
8 more