› 4b2r

Solution NMR

Solution structure of CCP modules 10-11 of complement factor H

Released:
DOI: 10.2210/pdb4b2r/pdb
PDB entry 4b2r coloured by chain, ensemble of 20 models, front view.
PDB entry 4b2r coloured by chain, ensemble of 20 models, side view.
PDB entry 4b2r coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H.
Makou E, Mertens HD, Maciejewski M, Soares DC, Matis I, Schmidt CQ, Herbert AP, Svergun DI, Barlow PN
J Mol Biol 424 295-312 (2012)
PMID: 23017427

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 566-687; Coverage: 10%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: simulated annealing
Expression system: Komagataella pastoris

Quick links

Citations

3 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
2 more

6 mentions without citation

New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3.
Rodriguez et al. (2014)
5 more