› 4b2z

X-ray diffraction
1.95Å resolution

Structure of Osh6 in complex with phosphatidylserine

Released:
DOI: 10.2210/pdb4b2z/pdb
PDB entry 4b2z coloured by chain, front view.
PDB entry 4b2z coloured by chain, side view.
PDB entry 4b2z coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins.
Maeda K, Anand K, Chiapparino A, Kumar A, Poletto M, Kaksonen M, Gavin AC
Nature 501 257-61 (2013)
PMID: 23934110

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169684 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Oxysterol-binding protein homolog 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 448 amino acids
Theoretical weight: 51.66 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02201 (Residues: 1-448; Coverage: 100%)
Gene names: OSH6, YK102, YKR003W
Sequence domains: Oxysterol-binding protein

Ligands and Environments

4 bound ligands:
Ligand SO4 2 x SO4
Ligand P5S 2 x P5S
Ligand DTU 1 x DTU
Ligand DTT 1 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 120Å b: 72.6Å c: 122.9Å
α: 90° β: 111.4° γ: 90°
R-values:
R R work R free
0.198 0.198 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

63 review citations

Lipid landscapes and pipelines in membrane homeostasis.
Holthuis et al. (2014)
62 more

7 mentions without citation

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Muller et al. (2019)
6 more