› 4b36

X-ray diffraction
1.76Å resolution

Crystal Structure of Human Angiogenin with an Engineered Loop Exhibits Conformational Flexibility at the Functional Regions of the Molecule

Released:
DOI: 10.2210/pdb4b36/pdb
PDB entry 4b36 coloured by chain, front view.
PDB entry 4b36 coloured by chain, side view.
PDB entry 4b36 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule.
Thiyagarajan N, Acharya KR
FEBS Open Bio 3 65-70 (2013)
PMID: 23772376

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137273 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiogenin Chains: A, B
Molecule details ›
Chains: A, B
Length: 126 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03950 (Residues: 25-147; Coverage: 100%)
Gene names: ANG, RNASE5
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX10.1
Spacegroup: P212121
Unit cell:
a: 38.353Å b: 54.676Å c: 94.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.236 0.285
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Angiogenin and Copper Crossing in Wound Healing.
Cucci et al. (2021)
1 more

5 mentions without citation

Structural genomics and the Protein Data Bank.
Michalska et al. (2021)
4 more