4b4n

X-ray diffraction
1.81Å resolution

CPSF6 defines a conserved capsid interface that modulates HIV-1 replication

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-109030 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retroviral nucleocapsid Gag protein p24 C-terminal domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.2 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: A9PKC6 (Residues: 33-178; Coverage: 53%)
Gene name: gag
Sequence domains: gag protein p24 N-terminal domain
Structure domains: Human Immunodeficiency Virus Type 1 Capsid Protein
Cleavage and polyadenylation specificity factor subunit 6 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.55 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q16630 (Residues: 276-290; Coverage: 3%)
Gene names: CFIM68, CPSF6

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 40.56Å b: 46.36Å c: 80.82Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.187 0.273
Expression system: Saccharomyces cerevisiae