› 4b7i

X-ray diffraction
2.36Å resolution

Crystal Structure of Human IgG Fc Bearing Hybrid-type Glycans

Released:
DOI: 10.2210/pdb4b7i/pdb
PDB entry 4b7i coloured by chain, front view.
PDB entry 4b7i coloured by chain, side view.
PDB entry 4b7i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis.
Bowden TA, Baruah K, Coles CH, Harvey DJ, Yu X, Song BD, Stuart DI, Aricescu AR, Scanlan CN, Jones EY, Crispin M
J Am Chem Soc 134 17554-63 (2012)
PMID: 23025485

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 218 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-329; Coverage: 53%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUC
Carbohydrate polymer
1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P212121
Unit cell:
a: 49.041Å b: 72.991Å c: 140.833Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.215 0.266
Expression system: Homo sapiens

Quick links

Citations

17 review citations

IgG subclasses and allotypes: from structure to effector functions.
Vidarsson et al. (2014)
16 more

7 mentions without citation

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation.
Watanabe et al. (2020)
6 more