› 4b7l

X-ray diffraction
2.05Å resolution

Crystal Structure of Human Filamin B Actin Binding Domain with 1st Filamin Repeat

Released:
DOI: 10.2210/pdb4b7l/pdb
PDB entry 4b7l coloured by chain, front view.
PDB entry 4b7l coloured by chain, side view.
PDB entry 4b7l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the filamin N-terminal region reveals a hinge between the actin binding and first repeat domains.
Sawyer GM, Sutherland-Smith AJ
J Mol Biol 424 240-7 (2012)
PMID: 23036857

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-B Chains: A, B
Molecule details ›
Chains: A, B
Length: 347 amino acids
Theoretical weight: 39.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75369 (Residues: 1-347; Coverage: 13%)
Gene names: FLN1L, FLN3, FLNB, TABP, TAP
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 72.18Å b: 69.69Å c: 73.46Å
α: 90° β: 111.1° γ: 90°
R-values:
R R work R free
0.185 0.183 0.219
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 citation in other articles

Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.
Duval et al. (2014)
3 more

2 mentions without citation

Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures.
Sivley et al. (2018)
1 more