› 4b99

X-ray diffraction
2.8Å resolution

Crystal Structure of MAPK7 (ERK5) with inhibitor

Released:
DOI: 10.2210/pdb4b99/pdb
PDB entry 4b99 coloured by chain, front view.
PDB entry 4b99 coloured by chain, side view.
PDB entry 4b99 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.
Elkins JM, Wang J, Deng X, Pattison MJ, Arthur JS, Erazo T, Gomez N, Lizcano JM, Gray NS, Knapp S
J Med Chem 56 4413-21 (2013)
PMID: 23656407

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 7 Chain: A
Molecule details ›
Chain: A
Length: 398 amino acids
Theoretical weight: 45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q13164 (Residues: 1-397; Coverage: 49%)
Gene names: BMK1, ERK5, MAPK7, PRKM7
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand R4L 1 x R4L
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P41212
Unit cell:
a: 95.15Å b: 95.15Å c: 119.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.287
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Kinase inhibitors: the road ahead.
Ferguson et al. (2018)
1 more

7 mentions without citation

Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.
Miller et al. (2023)
6 more